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Quantitative model for the binding affinity of intrinsically disordered proteins (IDP) to nano materials: SILC and FRIM models

This web server predicts and plots the binding profile of an intrinsically disordered protein (IDP) in solution to anionic silica nano-particle surface. Optionally, it also allows uploading and display of the experimental binding profile for comparison. The delta_R2 values correspond to the experimentally determined difference of 15N backbone transverse relaxation rates of IDP in presence and absence of the nanoparticles. The delta_R2 values are r elative measures of the interaction strengths of individual residues with the nanoparticles.

Reference

• M. Xie; D.W. Li; J.Q. Yuan and R. Brüschweiler. Dissecting the driving forces for residue-specific binding of intrinsically disordered proteins to nanoparticle surfaces; CHEMISTRY-A EUROPEAN JOURNAL (24) 16997, 2018

• D.W. Li; M. Xie and R. Brüschweiler. Quantitative cooperative binding model for intrinsically disordered proteins interacting with nanomaterials; (submitted)

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Acknowledgement

This web server and the research that led to it is supported by the National Science Foundation (Grant No. MCB-0918362)

*This information is only used for the compilation of our webserver usage data.

This server is last updated at March 15 2023 11:34:50.

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